Select Publications (view all publications)

The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane proteasome
Villalón Landeros E, Kho SC, Church TR, Brennan A, Türker F, Delannoy M, Caterina MJ, Margolis SS.
Cell Rep. 2024 Apr 8:114058. doi: 10.1016/j.celrep.2024.114058. Epub ahead of print. PMID: 38614084.

Neuronal membrane proteasome-derived peptides modulate NMDAR-dependent neuronal signaling to promote changes in gene expression
Türker F, Brennan A, Margolis SS.
Mol Biol Cell. 2024 Jan 1;35(1):ar6. doi: 10.1091/mbc.E23-06-0218. Epub 2023 Nov 1. PMID: 37910253; PMCID: PMC10881162.
Cover article

Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue
Türker F, Bharadwaj RA, Kleinman JE, Weinberger DR, Hyde TM, White CJ, Williams DW, Margolis SS.
J Biol Chem. 2023 Jun;299(6):104811. doi: 10.1016/j.jbc.2023.104811. Epub 2023 May 11. PMID: 37172721; PMCID: PMC10276296.

Neuronal membrane proteasomes regulate neuronal circuit activity in vivo and are required for learning-induced behavioral plasticity
He HY, Ahsan A, Bera R, McLain N, Faulkner R, Ramachandran KV, Margolis SS, Cline HT.
Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2216537120. doi: 10.1073/pnas.2216537120. Epub 2023 Jan 11. PMID: 36630455; PMCID: PMC9934054.

Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome
Ramachandran KV, Fu JM, Schaffer TB, Na CH, Delannoy M, Margolis SS.
Mol Cell. 2018 Jul 5;71(1):169-177.e6. doi: 10.1016/j.molcel.2018.06.013.

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function
Ramachandran KV, Margolis SS.
Nat Struct Mol Biol. 2017 Apr;24(4):419-430. doi: 10.1038/nsmb.3389.
Cover article

In Depth | Neuroscience
Is the cell’s garbage disposal sending messages?
Leslie M.
Science. 2017 Mar 31; 355(6332):1361. doi: 10.1126/science.355.6332.1361.

Deleting a UBE3A substrate rescues impaired hippocampal physiology and learning in Angelman syndrome mice
Sell GL, Xin W, Cook EK, Zbinden MA, Schaffer TB, O’Meally RN, Cole RN, Margolis SS.
Sci Rep. 2021 Sep 30;11(1):19414. doi: 10.1038/s41598-021-97898-w. PMID: 34593829; PMCID: PMC8484563.

PKCε inhibits neuronal dendritic spine development through dual phosphorylation of Ephexin5 at serine residues 107 and 109
Schaffer, TB, Smith, JE, Cook, EK, Phan, T, Margolis, SS.
Cell Rep. 2018 Nov 27;25(9):2470-2483.e8. doi: 10.1016/j.celrep.2018.11.005.

Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer’s-like impairment in mice
Sell GL, Schaffer TB, Margolis SS.
J Clin Invest. 2017 May 1;127(5):1646-1650. doi: 10.1172/JCI85504.

A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth
Hamilton AM, Lambert JT, Parajuli LK, Vivas O, Park DK, Stein IS, Jahncke JN, Greenberg ME, Margolis SS, Zito K.
Mol Cell Neurosci. 2017 Apr;80:66-74. doi: 10.1016/j.mcn.2017.02.001. Epub 2017 Feb 7.

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation
Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M, Greenberg ME.
Cell. 2010 Oct 29;143(3):442-55. doi: 10.1016/j.cell.2010.09.038.


Hats off to 20S proteasome substrate discovery
Church TR, Brennan A, Margolis SS.
Mol Syst Biol. 2024 Apr;20(4):293-295. doi: 10.1038/s44320-024-00028-7. Epub 2024 Mar 12. PMID: 38472306; PMCID: PMC10987484.

Proteasome cap particle regulates synapses
Türker F, Margolis SS.
Science. 2023 May 26;380(6647):795-796. doi: 10.1126/science.adi1166. Epub 2023 May 25. PMID: 37228187.

The proteasome and its role in the nervous system
Türker F, Cook EK, Margolis SS.
Cell Chem Biol. 2021 Jul 15;28(7):903-917. doi: 10.1016/j.chembiol.2021.04.003. Epub 2021 Apr 26. PMID: 33905676; PMCID: PMC8286317.

From UBE3A to Angelman syndrome: a substrate perspective
Sell, GL, and Margolis, SS.
Front Neurosci. 2015 Sep 15;9:322. doi: 10.3389/fnins.2015.00322. eCollection 2015. Review.

Angelman Syndrome
Margolis, SS, Sell, GL, Zbinden, MA, and Bird, LM.
Neurotherapeutics. 2015 Jul;12(3):641-50. doi: 10.1007/s13311-015-0361-y. Review.