Select Publications

The emergence of Ephexin5 as a therapeutic target in Alzheimer’s disease.
Cook EK, Sell GL, Schaffer TB, Margolis SS.
Expert Opin Ther Targets. 2019 Apr;23(4):263-265. doi: 10.1080/14728222.2019.1586884.

PKCε inhibits neuronal dendritic spine development through dual phosphorylation of Ephexin5 at serine residues 107 and 109.
Schaffer, TB, Smith, JE, Cook, EK, Phan, T, Margolis, SS.
Cell Rep. 2018 Nov 27;25(9):2470-2483.e8. doi: 10.1016/j.celrep.2018.11.005.

Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome.
Ramachandran KV, Fu JM, Schaffer TB, Na CH, Delannoy M, Margolis SS.
Mol Cell. 2018 Jul 5;71(1):169-177.e6. doi: 10.1016/j.molcel.2018.06.013.

Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer’s-like impairment in mice.
Sell GL, Schaffer TB, Margolis SS.
J Clin Invest. 2017 May 1;127(5):1646-1650. doi: 10.1172/JCI85504.

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function.
Ramachandran KV, Margolis SS.
Nat Struct Mol Biol. 2017 Apr;24(4):419-430. doi: 10.1038/nsmb.3389.
Cover article

In Depth | Neuroscience
Is the cell’s garbage disposal sending messages?
Leslie M.
Science. 2017 Mar 31; 355(6332):1361. doi: 10.1126/science.355.6332.1361.

A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth.
Hamilton AM, Lambert JT, Parajuli LK, Vivas O, Park DK, Stein IS, Jahncke JN, Greenberg ME, Margolis SS, Zito K.
Mol Cell Neurosci. 2017 Apr;80:66-74. doi: 10.1016/j.mcn.2017.02.001. Epub 2017 Feb 7.

From UBE3A to Angelman syndrome: a substrate perspective.
Sell, GL, and Margolis, SS.
Front Neurosci. 2015 Sep 15;9:322. doi: 10.3389/fnins.2015.00322. eCollection 2015. Review.

Angelman Syndrome.
Margolis, SS, Sell, GL, Zbinden, MA, and Bird, LM.
Neurotherapeutics. 2015 Jul;12(3):641-50. doi: 10.1007/s13311-015-0361-y. Review.

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.
Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M, Greenberg ME.
Cell. 2010 Oct 29;143(3):442-55. doi: 10.1016/j.cell.2010.09.038.


Deleting a UBE3A substrate rescues impaired hippocampal physiology and learning in Angelman syndrome mice.
Gabrielle SellWendy XinEmily CookMark ZbindenThomas SchafferRobert OMeallyRobert Cole,
Antonello BonciSeth Margolis. bioRxiv. 2019 May 2. doi: