Seth Shatkin Margolis, PhD

Associate Professor
Primary in Department of Biological Chemistry, Secondary in Department of Neuroscience

Seth Margolis is an Assistant Professor in the Department of Biological Chemistry (Link to )(primary appointment) and The Solomon H. Snyder Department of Neuroscience (Link to: ) (secondary appointment) in the Johns Hopkins University School of Medicine (Link to:

Seth received his PhD in cancer biology, working with Sally Kornbluth (Link to: in the Department of Pharmacology and Cancer Biology at Duke University School of Medicine.  As a graduate student Seth used biochemical and molecular approaches to decipher the protein signaling cascades critical for monitoring DNA responsive checkpoints that control timing of a cells transition into Mitosis (Link to graduate student publications).  He switched fields and completed a postdoc in developmental neuroscience, working with Michael E. Greenberg (Link to: in the Department of Neurobiology at Harvard Medical School. There, Seth investigated the molecular and cellular events important for determining in development of the hippocampus when and to what extent excitatory synapses were forming (Link to postdoc publication).  His postdoc research lead to the observation that critical players in the development of neuronal synapses are those that control the production and destruction of new proteins to maintain protein homeostasis. Seth moved to Johns Hopkins University School of Medicine in 2011 to start a laboratory using biochemical approaches to understand the molecular basis of protein homeostasis as it pertains to neuronal development in health and neurodevelopmental and neurodegenerative disease.

Seth loves to mentor students and just about anyone who walks into his office. Contact him by email or calling the office at (410) 502-5362.